DNA Damaging Agents in Chemical Biology and Cancer
نویسندگان
چکیده
منابع مشابه
CDK1 promotes nascent DNA synthesis and induces resistance of cancer cells to DNA-damaging therapeutic agents
Cyclin dependent kinase 1 (CDK1) is essential for cell viability and plays a vital role in many biological events including cell cycle control, DNA damage repair, and checkpoint activation. Here, we identify an unanticipated role for CDK1 in promoting nascent DNA synthesis during S-phase. We report that a short duration of CDK1 inhibition, which does not perturb cell cycle progression, triggers...
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The capacity of tumor cells for nucleotide excision repair (NER) is a major determinant of the efficacy of and resistance to DNA-damaging chemotherapeutics, such as cisplatin. Here, we demonstrate that using lesion-specific monoclonal antibodies, NER capacity is enhanced in human lung cancer cells after preconditioning with DNA-damaging agents. Preconditioning of cells with a nonlethal dose of ...
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Phosphate-solubilizing bacteria (PSBs) were isolated from different plant rhizosphere soils of various agroecological regions of India. These isolates showed synthesis of pyrroloquinoline quinone (PQQ), production of gluconic acid, and release of phosphorus from insoluble tricalcium phosphate. The bacterial isolates synthesizing PQQ also showed higher tolerance to ultraviolet C radiation and mi...
متن کاملInduction of fas RNA by DNA-damaging Agents
We have found that a wide variety of DNA-damaging agents and heat shock increase fas RNA to different extents in Chinese hamster ovary cells. These include the monofune! ional alkylating agents methylmethane sulfonate and A'-methyl-iV'-nitroWV-nitrosoguanidine, the cross-linking agents cis-Pt(II) diamminedichloride and mechlorethamine HC1, the DNA base-damaging agents 4-nitroquinolinc-,\'-o\idc...
متن کاملPolymerase η suppresses telomere defects induced by DNA damaging agents
Telomeres at chromosome ends are normally masked from proteins that signal and repair DNA double strand breaks (DSBs). Bulky DNA lesions can cause DSBs if they block DNA replication, unless they are bypassed by translesion (TLS) DNA polymerases. Here, we investigated roles for TLS polymerase η, (polη) in preserving telomeres following acute physical UVC exposure and chronic chemical Cr(VI) expo...
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ژورنال
عنوان ژورنال: CHIMIA International Journal for Chemistry
سال: 2020
ISSN: 0009-4293
DOI: 10.2533/chimia.2020.693